abstract：:Biosynthesis of 5,15-dihydroxyeicosatetraenoic acid (5,15-diHETE) in leukocytes involves consecutive oxygenation of arachidonic acid by 5-lipoxygenase (LOX) and 15-LOX in either order. Here, we analyzed the contribution of cyclooxygenase (COX)-2 to the biosynthesis of 5,15-diHETE and 5,11-diHETE in isolated human leuk...

journal_title：Journal of lipid research

authors： Tejera N,Boeglin WE,Suzuki T,Schneider C

更新日期：2012-01-01 00:00:00

abstract：:Sequence homology indicates the existence of three human cytosolic acyl protein thioesterases, including APT1 that is known to depalmitoylate H- and N-Ras. One of them is the lysophospholipase-like 1 (LYPLAL1) protein that on the one hand is predicted to be closely related to APT1 but on the other hand might also func...

journal_title：Journal of lipid research

authors： Bürger M,Zimmermann TJ,Kondoh Y,Stege P,Watanabe N,Osada H,Waldmann H,Vetter IR

更新日期：2012-01-01 00:00:00

abstract：:In an attempt to understand the applicability of various animal models to dyslipidemia in humans and to identify improved preclinical models for target discovery and validation for dyslipidemia, we measured comprehensive plasma lipid profiles in 24 models. These included five mouse strains, six other nonprimate specie...

journal_title：Journal of lipid research

authors： Yin W,Carballo-Jane E,McLaren DG,Mendoza VH,Gagen K,Geoghagen NS,McNamara LA,Gorski JN,Eiermann GJ,Petrov A,Wolff M,Tong X,Wilsie LC,Akiyama TE,Chen J,Thankappan A,Xue J,Ping X,Andrews G,Wickham LA,Gai CL,Trinh

更新日期：2012-01-01 00:00:00

abstract：:Choline kinase catalyzes the phosphorylation of choline, the first step of phospholipid synthesis. Increased phosphorylation of choline is a hallmark characteristic of the malignant phenotype in a variety of neoplasms. However, in hypoxic cancer cells, choline phosphorylation is decreased. To understand the mechanism ...

journal_title：Journal of lipid research

authors： Bansal A,Harris RA,DeGrado TR

更新日期：2012-01-01 00:00:00

abstract：:Mixed background SHP(-/-) mice are resistant to diet-induced obesity due to increased energy expenditure caused by enhanced PGC-1α expression in brown adipocytes. However, congenic SHP(-/-) mice on the C57BL/6 background showed normal expression of PGC-1α and other genes involved in brown adipose tissue thermogenesis....

journal_title：Journal of lipid research

authors： Park YJ,Kim SC,Kim J,Anakk S,Lee JM,Tseng HT,Yechoor V,Park J,Choi JS,Jang HC,Lee KU,Novak CM,Moore DD,Lee YK

更新日期：2011-12-01 00:00:00

abstract：:Maintaining cellular lipid homeostasis is crucial to oxidative tissues, and it becomes compromised in obesity. Lipid droplets (LD) play a central role in lipid homeostasis by mediating fatty acid (FA) storage in the form of triglyceride, thereby lowering intracellular levels of lipids that mediate cellular lipotoxicit...

journal_title：Journal of lipid research

authors： Wang H,Sreenivasan U,Hu H,Saladino A,Polster BM,Lund LM,Gong DW,Stanley WC,Sztalryd C

更新日期：2011-12-01 00:00:00

abstract：:Subnormal HDL-cholesterol (HDL-C) and apolipoprotein (apo)AI levels are characteristic of familial hypercholesterolemia (FH), reflecting perturbed intravascular metabolism with compositional anomalies in HDL particles, including apoE enrichment. Does LDL-apheresis, which reduces HDL-cholesterol, apoAI, and apoE by ads...

journal_title：Journal of lipid research

authors： Orsoni A,Saheb S,Levels JH,Dallinga-Thie G,Atassi M,Bittar R,Robillard P,Bruckert E,Kontush A,Carrié A,Chapman MJ

更新日期：2011-12-01 00:00:00

abstract：:A-C1 protein is the product of a tumor suppressor gene negatively regulating the oncogene Ras and belongs to the HRASLS (HRAS-like suppressor) subfamily. We recently found that four members of this subfamily expressed in human tissues function as phospholipid-metabolizing enzymes. Here we examined a possible enzyme ac...

journal_title：Journal of lipid research

authors： Shinohara N,Uyama T,Jin XH,Tsuboi K,Tonai T,Houchi H,Ueda N

更新日期：2011-11-01 00:00:00

abstract：:Seven Z-octadecenoic acids having the double bond located in positions 6Z to 13Z were photooxidized. The resulting hydroperoxy-E-octadecenoic acids [HpOME(E)] were resolved by chiral phase-HPLC-MS, and the absolute configurations of the enantiomers were determined by gas chromatographic analysis of diastereoisomeric d...

journal_title：Journal of lipid research

authors： Oliw EH,Wennman A,Hoffmann I,Garscha U,Hamberg M,Jernerén F

更新日期：2011-11-01 00:00:00

abstract：:Consumption of industrially produced trans fatty acids (IP-TFA) has been positively associated with systemic markers of low-grade inflammation and endothelial dysfunction in cross-sectional studies, but results from intervention studies are inconclusive. Therefore, we conducted a 16 week double-blind parallel interven...

journal_title：Journal of lipid research

authors： Bendsen NT,Stender S,Szecsi PB,Pedersen SB,Basu S,Hellgren LI,Newman JW,Larsen TM,Haugaard SB,Astrup A

更新日期：2011-10-01 00:00:00

abstract：:The pregnane X receptor (PXR, also known as SXR) is a nuclear hormone receptor activated by xenobiotics as well as diverse sterols and their metabolites. PXR functions as a xenobiotic sensor to coordinately regulate xenobiotic metabolism via transcriptional regulation of xenobiotic-detoxifying enzymes and transporters...

journal_title：Journal of lipid research

authors： Sui Y,Xu J,Rios-Pilier J,Zhou C

更新日期：2011-09-01 00:00:00

abstract：:Triacylglycerols (TG) are the major storage form of energy in eukaryotic organisms and are synthesized primarily by acyl CoA:1,2-diacylglycerol acyltransferase (DGAT) enzymes. In vitro DGAT activity has previously been quantified by measuring the incorporation of either radiolabeled fatty acyl CoA or diacylglycerol (D...

journal_title：Journal of lipid research

authors： McFie PJ,Stone SJ

更新日期：2011-09-01 00:00:00

abstract：:Apolipoprotein A-II (apoA-II) is the second major apolipoprotein following apolipoprotein A-I (apoA-I) in HDL. ApoA-II has multiple physiological functions and can form senile amyloid fibrils (AApoAII) in mice. Most circulating apoA-II is present in lipoprotein A-I/A-II. To study the influence of apoA-I on apoA-II and...

journal_title：Journal of lipid research

authors： Wang Y,Sawashita J,Qian J,Zhang B,Fu X,Tian G,Chen L,Mori M,Higuchi K

更新日期：2011-08-01 00:00:00

abstract：:Animal studies have suggested that angiopoietin-like 4 (Angptl4) regulates adiposity through central and peripheral mechanisms. The aim of this study was to investigate whether serum concentration and adipose tissue expression of Angptl4 are associated with obesity-related parameters in humans. Altogether, 75 dizygoti...

journal_title：Journal of lipid research

authors： Robciuc MR,Naukkarinen J,Ortega-Alonso A,Tyynismaa H,Raivio T,Rissanen A,Kaprio J,Ehnholm C,Jauhiainen M,Pietiläinen KH

更新日期：2011-08-01 00:00:00

abstract：:Vitamin E (α-tocopherol) is the major lipid-soluble antioxidant in many species. Niemann-Pick type C (NPC) disease is a lysosomal storage disorder caused by mutations in the NPC1 or NPC2 gene, which regulates lipid transport through the endocytic pathway. NPC disease is characterized by massive intracellular accumulat...

journal_title：Journal of lipid research

authors： Ulatowski L,Parker R,Davidson C,Yanjanin N,Kelley TJ,Corey D,Atkinson J,Porter F,Arai H,Walkley SU,Manor D

更新日期：2011-07-01 00:00:00

abstract：:Niemann-Pick disease, type C (NP-C), often associated with Niemann-Pick disease, type C1 (NPC1) mutations, is a cholesterol-storage disorder characterized by cellular lipid accumulation, neurodegeneration, and reduced steroid production. To study NPC1 function in vivo, we cloned zebrafish npc1 and analyzed its gene ex...

journal_title：Journal of lipid research

authors： Schwend T,Loucks EJ,Snyder D,Ahlgren SC

更新日期：2011-07-01 00:00:00

abstract：:Genome-wide association (GWA) studies represent a powerful strategy for identifying susceptibility genes for complex diseases in human populations but results must be confirmed and replicated. Because of the close homology between mouse and human genomes, the mouse can be used to add evidence to genes suggested by hum...

journal_title：Journal of lipid research

authors： Leduc MS,Lyons M,Darvishi K,Walsh K,Sheehan S,Amend S,Cox A,Orho-Melander M,Kathiresan S,Paigen B,Korstanje R

更新日期：2011-06-01 00:00:00

abstract：:In this study, we investigated the hypothesis that regulatory T cells (T(reg)) are involved in the immunomodulatory effects of statins on rheumatoid arthritis (RA) patients. The 12-week study cohort consisted of 55 RA patients and 42 control subjects allocated to either a group treated with atorvastatin (AT) (20 mg/da...

journal_title：Journal of lipid research

authors： Tang TT,Song Y,Ding YJ,Liao YH,Yu X,Du R,Xiao H,Yuan J,Zhou ZH,Liao MY,Yao R,Jevallee H,Shi GP,Cheng X

更新日期：2011-05-01 00:00:00

abstract：:Inflammation has been proposed to impair HDL function and reverse cholesterol transport (RCT). We investigated the effects of inflammation mediated by zymosan, a yeast glucan, on multiple steps along the RCT pathway in vivo and ex vivo. Acute inflammation with 70 mg/kg zymosan impaired RCT to plasma, liver, and feces ...

journal_title：Journal of lipid research

authors： Malik P,Berisha SZ,Santore J,Agatisa-Boyle C,Brubaker G,Smith JD

更新日期：2011-05-01 00:00:00

abstract：:Hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) is the rate-controlling enzyme of cholesterol synthesis, and owing to its biological and pharmacological relevance, researchers have investigated several compounds capable of modulating its activity with the hope of developing new hypocholesterolemic drugs. In particular,...

journal_title：Journal of lipid research

authors： Cuccioloni M,Mozzicafreddo M,Spina M,Tran CN,Falconi M,Eleuteri AM,Angeletti M

更新日期：2011-05-01 00:00:00

abstract：:(13)C-Cholesterol was produced with high efficiency by a genetically engineered yeast strain. The method produces ∼ 1 mg of cholesterol per gram of glucose using 100 ml of culture medium. Uniform 94% enrichment where the most abundant product is the fully enriched isotopomer (u-(13)C(27)) is obtained using (u-(13)C(6)...

journal_title：Journal of lipid research

authors： Shivapurkar R,Souza CM,Jeannerat D,Riezman H

更新日期：2011-05-01 00:00:00

abstract：:Long-chain acyl-CoA synthetases (ACSLs) catalyze the thioesterification of long-chain FAs into their acyl-CoA derivatives. Purified ACSL4 is an arachidonic acid (20:4)-preferring ACSL isoform, and ACSL4 is therefore a probable regulator of lipid mediator production in intact cells. Eicosanoids play important roles in ...

journal_title：Journal of lipid research

authors： Golej DL,Askari B,Kramer F,Barnhart S,Vivekanandan-Giri A,Pennathur S,Bornfeldt KE

更新日期：2011-04-01 00:00:00

abstract：:Hepatic steatosis is one of the most common liver disorders in the general population. The main cause of hepatic steatosis is nonalcoholic fatty liver disease (NAFLD), representing the hepatic component of the metabolic syndrome, which is characterized by type 2 diabetes, obesity, and dyslipidemia. Insulin resistance ...

journal_title：Journal of lipid research

authors： Hooper AJ,Adams LA,Burnett JR

更新日期：2011-04-01 00:00:00

abstract：:We examined the association between rate of cholesterol esterification in plasma depleted of apolipoprotein B-containing lipoproteins (FER(HDL)), atherogenic index of plasma (AIP) [(log (TG/HDL-C)], concentrations, and size of lipoproteins and changes in coronary artery stenosis in participants in the HDL-Atherosclero...

journal_title：Journal of lipid research

authors： Dobiásová M,Frohlich J,Sedová M,Cheung MC,Brown BG

更新日期：2011-03-01 00:00:00

abstract：:The enzyme 1-acylglycerol-3-phosphate-O-acyltransferase (AGPAT) converts lysophosphatidic acid (LPA) to phosphatidic acid (PA). In this study, we show enzymatic properties, tissue distribution, and subcellular localization of human AGPAT3 and AGPAT5. In cells overexpressing these isoforms, the proteins were detected i...

journal_title：Journal of lipid research

authors： Prasad SS,Garg A,Agarwal AK

更新日期：2011-03-01 00:00:00

abstract：:A novel water-soluble polysaccharide fraction, CME-1, with a molecular mass of 27.6 kDa and containing mannose and galactose in a respective ratio of 4:6, was prepared from Cordyceps sinensis mycelia and identified by NMR and GC-MS. In the current study, we examined whether CME-1 has anti-inflammatory effects in RAW26...

journal_title：Journal of lipid research

authors： Wang SH,Yang WB,Liu YC,Chiu YH,Chen CT,Kao PF,Lin CM

更新日期：2011-03-01 00:00:00

abstract：:Apolipoprotein (apo)E is well established as a secreted protein that plays an important role in systemic lipoprotein metabolism and vascular wall homeostasis. Recently, endogenous expression of apoE in adipocytes has been shown to play an important role in adipocyte lipoprotein metabolism and gene expression consisten...

journal_title：Journal of lipid research

authors： Yue L,Mazzone T

更新日期：2011-03-01 00:00:00

abstract：:In vivo single-voxel magnetic resonance spectroscopy (MRS) at 4.7T and ex vivo high-resolution proton magnetic resonance spectroscopy (HR-NMR) at 500 MHz were used to study the composition of adipose tissues in Zucker obese and Zucker lean rats. Lipid composition was characterized by unsaturation and polyunsaturation ...

journal_title：Journal of lipid research

authors： Mosconi E,Fontanella M,Sima DM,Van Huffel S,Fiorini S,Sbarbati A,Marzola P

更新日期：2011-02-01 00:00:00

abstract：:ATP binding cassette transporter G1 (ABCG1) mediates the transport of cellular cholesterol to HDL, and it plays a key role in maintaining macrophage cholesterol homeostasis. During inflammation, HDL undergoes substantial remodeling, acquiring lipid changes and serum amyloid A (SAA) as a major apolipoprotein. In the cu...

journal_title：Journal of lipid research

authors： de Beer MC,Ji A,Jahangiri A,Vaughan AM,de Beer FC,van der Westhuyzen DR,Webb NR

更新日期：2011-02-01 00:00:00

abstract：:Each abdominal fat depot, such as mesenteric or epididymal, differently contributes to the development of insulin resistance. The aim of this study was to identify the genetic regions that contribute to fat accumulation in epididymal/mesenteric fat and to examine whether or not the genetic regions that affect glucose ...

journal_title：Journal of lipid research

authors： Kobayashi M,Ohno T,Hada N,Fujiyoshi M,Kuga M,Nishimura M,Murai A,Horio F

更新日期：2010-12-01 00:00:00

abstract：:The mechanisms involved in the development of alcoholic liver disease (ALD) are not well established. We investigated the involvement of acyl-CoA: diacylglycerol acyltransferase 2 (DGAT2) upregulation in mediating hepatic fat accumulation induced by chronic alcohol consumption. Chronic alcohol feeding caused fatty liv...

journal_title：Journal of lipid research

authors： Wang Z,Yao T,Song Z

更新日期：2010-11-01 00:00:00

abstract：:Lipid and cholesterol metabolism in the postprandial phase is associated with both quantitative and qualitative remodeling of HDL particle subspecies that may influence their anti-atherogenic functions in the reverse cholesterol transport pathway. We evaluated the capacity of whole plasma or isolated HDL particles to ...

journal_title：Journal of lipid research

authors： Julia Z,Duchene E,Fournier N,Bellanger N,Chapman MJ,Le Goff W,Guerin M

更新日期：2010-11-01 00:00:00

abstract：:Proprotein convertase, subtilisin/kexin type 9 (PCSK9), a key regulator of plasma LDL-cholesterol (LDL-c) and cardiovascular risk, is produced in liver and secreted into plasma where it binds hepatic LDL receptors (LDLR), leading to their degradation. PCSK9 is transcriptionally activated by sterol response element-bin...

journal_title：Journal of lipid research

authors： Browning JD,Horton JD

更新日期：2010-11-01 00:00:00

abstract：:Sebum is a complex lipid mixture that is synthesized in sebaceous glands and excreted on the skin surface. The purpose of this study was the comprehensive detection of the intact lipids that compose sebum. These lipids exist as a broad range of chemical structures and concentrations. Sebum was collected with SebuTape(...

journal_title：Journal of lipid research

authors： Camera E,Ludovici M,Galante M,Sinagra JL,Picardo M

更新日期：2010-11-01 00:00:00

abstract：:N-acylethanolamines (NAEs) are a group of lipid mediators synthesized in response to a number of physiological and pathological stimuli. Because of the low tissue concentrations of NAEs, analyses often include liquid extraction followed by solid-phase extraction and subsequent quantitation by LC/MS or GC/MS. Reported ...

journal_title：Journal of lipid research

authors： Skonberg C,Artmann A,Cornett C,Hansen SH,Hansen HS

更新日期：2010-10-01 00:00:00

abstract：:In humans, peroxisomes harbor a complex set of enzymes acting on various lipophilic carboxylic acids, organized in two basic pathways, alpha-oxidation and beta-oxidation; the latter pathway can also handle omega-oxidized compounds. Some oxidation products are crucial to human health (primary bile acids and polyunsatur...

journal_title：Journal of lipid research

authors： Van Veldhoven PP

更新日期：2010-10-01 00:00:00

abstract：:Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that regulates hepatic low-density lipoprotein receptor (LDLR) levels in humans. PCSK9 has also been shown to regulate the levels of additional membrane-bound proteins in vitro, including the very low-density lipoprotein receptor (VLDLR), apol...

journal_title：Journal of lipid research

authors： Liu M,Wu G,Baysarowich J,Kavana M,Addona GH,Bierilo KK,Mudgett JS,Pavlovic G,Sitlani A,Renger JJ,Hubbard BK,Fisher TS,Zerbinatti CV

更新日期：2010-09-01 00:00:00

abstract：:The ability to exogenously present cell-surface receptors in high-affinity conformations in a synthetic system offers an opportunity to provide host cells with protection from pathogenic toxins. This strategy requires improvement of the synthetic receptor binding affinity against its native counterpart, particularly w...

journal_title：Journal of lipid research

authors： Bricarello DA,Mills EJ,Petrlova J,Voss JC,Parikh AN

更新日期：2010-09-01 00:00:00

abstract：:ATP-citrate lyase (ACL) is a key lipogenic enzyme that converts citrate in the cytoplasm to acetyl-CoA, the initial precursor that yields malonyl-CoA for fatty acid biosynthesis. As cytosolic citrate is derived from the tricarboxylic acid cycle in the mitochondrion, ACL catalyzes a critical reaction linking cellular g...

journal_title：Journal of lipid research

authors： Wang Q,Li S,Jiang L,Zhou Y,Li Z,Shao M,Li W,Liu Y

更新日期：2010-09-01 00:00:00

abstract：:An online, two-dimensional (2D) liquid chromatography (LC) quadrupole time-of-flight mass spectrometry (QToF-MS) method was developed for lipid profiling of rat peritoneal surface layers, in which the lipid classes and species could be simultaneously separated in one injection with a significantly increased sensitivit...

journal_title：Journal of lipid research

authors： Nie H,Liu R,Yang Y,Bai Y,Guan Y,Qian D,Wang T,Liu H

更新日期：2010-09-01 00:00:00